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Neurofibromatosis type 1 — SCE Dermatology MCQ

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HardPaediatric and geneticsNeurofibromatosis type 1SCE Dermatology

A child with confirmed NF1 attends annual review and feels well. Which measurement should remain part of routine surveillance because NF1 vasculopathy and catecholamine-secreting tumours may present silently?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Annual blood-pressure measurement interpreted against paediatric centiles

Explanation lettering: B = shown as A · E = shown as B · A = shown as D · D = shown as E

D is correct. Blood pressure belongs in routine NF1 surveillance because renal artery stenosis and, later, phaeochromocytoma can cause hypertension. Routine whole-body MRI, catecholamine screening without an indication, biopsy of ordinary neurofibromas and lumbar puncture are not standard surveillance substitutes for careful annual clinical review.

Reference: NHS Genomics Education Programme: neurofibromatosis type 1: https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/neurofibromatosis-type-1/