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Severe agitation with stimulant intoxication — ABEM Board MCQ

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HardPsychiatric emergenciesSevere agitation with stimulant intoxicationABEM Board

A 49-year-old man arrives as ESI 2 with severe agitation after using methamphetamine. BP 196/106, HR 152, temperature 39.8 C. He is diaphoretic and combative with CK 4200 U/L. Which of the following is the most appropriate initial action?

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Correct answer: EAdminister benzodiazepines, active cooling, and IV fluids

Sympathomimetic toxicity is managed with benzodiazepines, cooling, and fluids; agitation control reduces hyperthermia and rhabdomyolysis.

Reference: ACEP severe agitation policy; Goldfrank Toxicologic Emergencies