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Rifampicin counselling — GPhC CRA MCQ

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ModerateInfectionsRifampicin counsellingGPhC CRA

A 36-year-old woman is prescribed rifampicin and isoniazid for TB. She takes a combined oral contraceptive and asks whether the orange urine means kidney damage. She has no dysuria or loin pain. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Explain orange body fluids can occur and arrange additional contraception advice

Rifampicin commonly discolours urine, sweat and tears orange-red, which should be explained. It is also a potent enzyme inducer and reduces effectiveness of combined hormonal contraception. The pharmacist should advise appropriate additional or alternative contraception through specialist guidance.

Reference: BNF; UKHSA TB guidance