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ACE inhibitor angioedema — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyACE inhibitor angioedemaGPhC CRA

A 57-year-old man with hypertension is prescribed ramipril 5mg daily. Two weeks later he develops facial swelling, lip swelling and mild throat tightness. He asks to buy chlorphenamine because he thinks it is hay fever. What is the most appropriate action?

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Correct answer: C — Call emergency services because ACE inhibitor angioedema is possible

Facial and lip swelling with throat tightness in a patient taking an ACE inhibitor suggests angioedema. Airway involvement can progress and requires emergency assessment. Ramipril should not be continued pending urgent review.

Reference: BNF; NICE CKS