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Amlodipine ankle oedema — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsAmlodipine ankle oedemaGPhC CRA

A 53-year-old woman with hypertension is prescribed amlodipine 10mg daily. She reports ankle swelling after dose escalation, but no breathlessness, no calf pain and blood pressure is now controlled. She asks whether a water tablet is needed. What is the most appropriate alternative?

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Correct answer: ADiscuss dose reduction or switching antihypertensive with the prescriber

Ankle oedema is a common dose-related adverse effect of dihydropyridine calcium-channel blockers. Diuretics are often ineffective because the mechanism is not simple fluid overload. The prescriber may reduce the dose or switch therapy while maintaining blood pressure control.

Reference: BNF; NICE CKS