Tramadol with SSRI and epilepsy — GPhC CRA MCQ
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Correct answer: A — Tramadol increases seizure and serotonin toxicity risk with this history
Tramadol can lower seizure threshold and has serotonergic activity. Sertraline and a history of epilepsy make the prescription higher risk. The pharmacist should contact the prescriber to consider safer analgesia before travel.
Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment