skip to main content

Nitrofurantoin pulmonary hepatic toxicity — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardAdverse Drug Reactions and Drug SafetyNitrofurantoin pulmonary hepatic toxicityGPhC CRA

A 66-year-old woman is prescribed nitrofurantoin 100mg modified-release nightly for recurrent UTI prophylaxis. She reports new breathlessness, dry cough and dark urine after three months. Her eGFR is 51mL/min/1.73m2. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Stop supply and refer urgently for review of pulmonary and hepatic toxicity

Nitrofurantoin can cause pulmonary and hepatic adverse reactions, particularly with longer-term use. New respiratory symptoms and dark urine are concerning warning features. The pharmacist should refer urgently and ensure the prescriber reviews ongoing prophylaxis.

Reference: MHRA; BNF