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Pregabalin dose in CKD — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentPregabalin dose in CKDGPhC CRA

A 73-year-old man with CKD stage 4 is prescribed pregabalin 150mg twice daily for neuropathic pain. His eGFR is 24mL/min/1.73m2 and he has had two recent falls. He also takes zopiclone at night. What monitoring is required?

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Correct answer: C — Renal function, sedation, dizziness and falls risk review

Pregabalin requires dose adjustment in renal impairment and can cause dizziness or sedation. CKD stage 4, recent falls and zopiclone use raise the risk of harm. Monitoring should focus on renal function, CNS adverse effects and falls, with prescriber review of the dose.

Reference: BNF; NICE CKS