Methotrexate monitoring counselling — GPhC CRA MCQ
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Correct answer: E — Withhold methotrexate and arrange urgent assessment for pneumonitis or infection
Methotrexate pneumonitis and serious infection can present with fever, cough, dyspnoea and hypoxaemia. Both are potentially life-threatening and require urgent assessment, chest investigation and treatment review. Trimethoprim adds dangerous marrow-toxicity risk.
Reference: BNF: methotrexate: https://bnf.nice.org.uk/drugs/methotrexate/