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Domperidone QT risk — GPhC CRA MCQ

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HardGI TherapeuticsDomperidone QT riskGPhC CRA

A 45-year-old man is prescribed domperidone 10mg three times daily for nausea. His medicines include amiodarone 200mg daily and citalopram 20mg daily. His last ECG showed QTc prolongation. What is the most appropriate alternative?

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Correct answer: D — Ask the prescriber to choose an antiemetic with lower QT concern

Domperidone is associated with QT prolongation and arrhythmia risk. Amiodarone, citalopram and previous QTc prolongation make the prescription high risk. The pharmacist should contact the prescriber for an alternative and review of modifiable risk factors.

Reference: BNF; MHRA Drug Safety Update