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Pneumonia antibiotic with statin interaction — GPhC CRA MCQ

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ModerateRespiratory TherapeuticsPneumonia antibiotic with statin interactionGPhC CRA

A 71-year-old man is prescribed clarithromycin for community-acquired pneumonia. He takes atorvastatin 80mg daily after a recent stroke and amlodipine 10mg daily. He has muscle pain from a previous statin. What is the most appropriate alternative?

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Correct answer: B — Ask the prescriber about an alternative antibiotic or temporary statin interruption

Clarithromycin can increase exposure to statins metabolised through CYP3A pathways and increase myopathy risk. The high statin dose and previous muscle symptoms increase concern. The pharmacist should contact the prescriber to agree a safe antibiotic or statin plan.

Reference: BNF; NICE CKS