Bisphosphonate counselling — GPhC CRA MCQ
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Correct answer: A — Continue treatment pending review and use contraception for three months after cessation
MHRA precautionary advice recommends effective contraception during paternal valproate exposure and for at least three months after stopping to allow a sperm-development cycle without exposure. Men planning a family should receive specialist review of alternatives, but valproate must not be stopped abruptly because seizure or disease control may deteriorate. The advice concerns both the man and partner and cannot be met by self-directed switching.
Reference: MHRA: valproate use in men. https://www.gov.uk/drug-safety-update/valproate-use-in-men-as-a-precaution-men-and-their-partners-should-use-effective-contraception