A 55-year-old woman takes omeprazole 20mg daily and clopidogrel 75mg daily after a recent NSTEMI. Her GP asks whether continuing omeprazole is

Question

A 55-year-old woman takes omeprazole 20mg daily and clopidogrel 75mg daily after a recent NSTEMI. Her GP asks whether continuing omeprazole is acceptable because she has recurrent dyspepsia. She has no history of GI bleeding. What is the most important interaction to flag?

Accepted Answer

Omeprazole may reduce activation and antiplatelet effect of clopidogrel

Answer

Omeprazole may cause severe hypoglycaemia with clopidogrel

Answer

Clopidogrel may increase omeprazole renal clearance

Answer

Omeprazole may increase clopidogrel absorption and bleeding

Answer

Clopidogrel may reduce omeprazole acid suppression

Clopidogrel and omeprazole — GPhC CRA MCQ

A 55-year-old woman takes omeprazole 20mg daily and clopidogrel 75mg daily after a recent NSTEMI. Her GP asks whether continuing omeprazole is acceptable because she has recurrent dyspepsia. She has no history of GI bleeding. What is the most important interaction to flag?