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Carbimazole agranulocytosis — GPhC CRA MCQ

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HardEndocrine TherapeuticsCarbimazole agranulocytosisGPhC CRA

A 60-year-old woman is prescribed carbimazole 20mg daily. Three weeks later she asks for paracetamol for fever and sore throat. She also reports mouth ulcers and feels unusually tired. What is the most appropriate action?

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Correct answer: C — Advise stopping carbimazole and seeking urgent full blood count assessment

Sore throat, fever and mouth ulcers while taking carbimazole can indicate agranulocytosis. The patient needs urgent assessment including full blood count and advice to stop carbimazole pending review. Treating the symptoms without escalation would miss a serious adverse reaction.

Reference: BNF; NICE CKS