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Lamotrigine severe rash — GPhC CRA MCQ

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HardCNS TherapeuticsLamotrigine severe rashGPhC CRA

A 38-year-old man with epilepsy has a new widespread rash and mouth ulcers two weeks after starting lamotrigine. He has a temperature of 38.4C and feels unwell. He asks whether he can buy an antihistamine. What is the most appropriate action?

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Correct answer: E — Refer for same-day urgent medical assessment

A rash with mucosal involvement and fever after starting lamotrigine may indicate a severe cutaneous adverse reaction. The systemic features distinguish this from simple urticaria. The patient needs urgent assessment and specialist advice about lamotrigine continuation.

Reference: BNF; MHRA