skip to main content

Methotrexate weekly dosing error — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardMusculoskeletal TherapeuticsMethotrexate weekly dosing errorGPhC CRA

A 49-year-old woman with rheumatoid arthritis collects methotrexate 2.5mg tablets. The prescription reads 10mg daily, but her previous dose was 10mg once weekly and folic acid 5mg once weekly. She says the hospital recently increased her dose. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Contact the prescriber urgently to clarify the methotrexate frequency

Daily methotrexate for inflammatory disease is a high-risk prescribing error unless explicitly intended for a different indication. The previous weekly regimen and folic acid pattern strongly suggest an error. The pharmacist should not supply until the dose and frequency are clarified.

Reference: BNF; MHRA; MEP