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Fluconazole and citalopram — GPhC CRA MCQ

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HardDrug InteractionsFluconazole and citalopramGPhC CRA

A 41-year-old woman asks to buy fluconazole 150mg for vaginal candidiasis. Her medication history shows citalopram 40mg daily and she recently had palpitations investigated. She has no pregnancy risk. What is the most important interaction to flag?

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Correct answer: A — Fluconazole may increase QT prolongation risk with citalopram

Citalopram has dose-related QT prolongation risk, and fluconazole can add QT risk and inhibit metabolism. The history of palpitations increases the need for caution rather than routine OTC sale. A pharmacist should assess suitability and consider referral or an alternative approach.

Reference: BNF; MHRA Drug Safety Update