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Apixaban dose reduction — GPhC CRA MCQ

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HardCardiovascular TherapeuticsApixaban dose reductionGPhC CRA

A 79-year-old man is discharged on apixaban 2.5mg twice daily for AF. His weight is 58kg, age is 79 years and serum creatinine is 118micromol/L. The discharge summary says the dose was reduced because he is frail. What is the most appropriate action?

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Correct answer: E — Query the apixaban dose with the prescriber before supply

Apixaban dose reduction for AF is based on defined criteria rather than frailty alone. This patient appears to meet weight below 60kg but not the age or serum creatinine criteria required for routine reduction. Under-dosing may reduce stroke prevention, so the pharmacist should query before dispensing.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-98