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Diabetic ketoacidosis with hypokalaemia — SCE Acute Medicine MCQ

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EasyDiabetes and endocrine medicineDiabetic ketoacidosis with hypokalaemiaSCE Acute Medicine

A 24-year-old woman with type 1 diabetes presents with vomiting and abdominal pain after missed insulin. Glucose is 28 mmol/L, ketones 6.1 mmol/L, pH 7.18, bicarbonate 9 mmol/L and potassium 3.2 mmol/L. She is dehydrated but alert. What is the most appropriate next step in management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: AStart intravenous fluids and potassium replacement before fixed-rate insulin infusion

DKA requires fluids, ketone clearance with insulin and potassium management, but potassium of 3.2 mmol/L means replacement is needed before insulin because insulin will drive potassium intracellularly. Routine bicarbonate is not indicated at this pH in standard DKA care. The major safety issue is avoiding treatment-induced hypokalaemia.

Reference: Joint British Diabetes Societies guideline for DKA; NICE CKS diabetic ketoacidosis