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Statin-associated rhabdomyolysis — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyStatin-associated rhabdomyolysisGPhC CRA

A 62-year-old man develops muscle pain, weakness and dark urine after starting atorvastatin 80 mg and clarithromycin. He has CKD stage 3. What monitoring is required?

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Correct answer: A — Urgent creatine kinase and renal function assessment

Muscle symptoms with dark urine suggest possible rhabdomyolysis, especially with high-dose statin, macrolide interaction and CKD. CK and renal function should be assessed urgently. The statin and interacting antibiotic should be reviewed promptly by a prescriber.

Reference: BNF; MHRA Drug Safety Update