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Clopidogrel and omeprazole — GPhC CRA MCQ

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ModerateDrug InteractionsClopidogrel and omeprazoleGPhC CRA

A patient taking clopidogrel after a coronary stent is prescribed omeprazole 20 mg daily for dyspepsia. He has no history of GI bleed and asks whether he can start it today. What is the most appropriate alternative?

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Correct answer: D — Discuss lansoprazole or pantoprazole with the prescriber

Omeprazole can reduce activation of clopidogrel via CYP2C19 inhibition. Where gastroprotection is needed, PPIs with less interaction potential are generally preferred. Timing separation does not reliably avoid the interaction.

Reference: BNF