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Theophylline and ciprofloxacin — GPhC CRA MCQ

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HardDrug InteractionsTheophylline and ciprofloxacinGPhC CRA

A patient on theophylline MR 300 mg twice daily is prescribed ciprofloxacin for a suspected UTI. She reports nausea and palpitations after two doses and is a non-smoker. What is the most important interaction to flag?

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Correct answer: C — Ciprofloxacin may increase theophylline toxicity

Ciprofloxacin can increase theophylline levels and toxicity, causing nausea, palpitations, tremor or seizures. The symptoms after starting treatment are concerning. The pharmacist should contact the prescriber urgently and consider the need for theophylline level assessment.

Reference: BNF