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Amiodarone and warfarin — GPhC CRA MCQ

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HardDrug InteractionsAmiodarone and warfarinGPhC CRA

A 71-year-old man taking amiodarone 200 mg daily is prescribed warfarin for AF after admission. He also takes levothyroxine and has baseline INR 1.1. What monitoring is required?

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Correct answer: E — Close INR monitoring after warfarin initiation

Amiodarone can enhance the anticoagulant effect of warfarin, often requiring dose adjustment and close INR monitoring. The interaction may develop over time because of amiodarone's long half-life. Thyroid status can also affect warfarin sensitivity, so careful follow-up is important.

Reference: BNF