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Potassium salt with ACE inhibitor and MRA — GPhC CRA MCQ

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HardDrug InteractionsPotassium salt with ACE inhibitor and MRAGPhC CRA

A 64-year-old man on ramipril and spironolactone asks to buy potassium citrate mixture for urinary discomfort. His latest potassium was 5.2 mmol/L and eGFR 44 mL/min/1.73 m2. What is the most important interaction to flag?

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Correct answer: E — Potassium salts with ramipril and spironolactone increase hyperkalaemia risk

ACE inhibitors and spironolactone both increase serum potassium. Adding potassium salts in a patient with CKD and existing borderline hyperkalaemia could be dangerous. The urinary symptoms also need assessment for infection or other causes rather than routine alkalinisation.

Reference: BNF