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Rifampicin and contraception — GPhC CRA MCQ

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HardDrug InteractionsRifampicin and contraceptionGPhC CRA

A woman taking the combined oral contraceptive is prescribed rifampicin for latent TB. She asks whether she needs extra contraception because she has been adherent with her pill. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Use an effective non-hormonal method and seek contraception review

Rifampicin is a potent enzyme inducer and can reduce hormonal contraceptive efficacy. A non-hormonal method such as copper intrauterine contraception, or specialist contraceptive advice, is needed. Simply taking the pill at a different time will not overcome enzyme induction.

Reference: BNF; FSRH guidance