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Benzodiazepine in liver disease — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentBenzodiazepine in liver diseaseGPhC CRA

A 58-year-old woman with decompensated cirrhosis is prescribed diazepam 5 mg three times daily for back spasm. She has recent hepatic encephalopathy and takes lactulose. What is the most appropriate action?

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Correct answer: A — Query the prescription because of encephalopathy and sedation risk

Benzodiazepines can worsen sedation and precipitate or exacerbate hepatic encephalopathy in decompensated liver disease. Her recent encephalopathy makes this a high-risk prescription. The pharmacist should contact the prescriber for reassessment and safer management.

Reference: BNF; NICE CKS