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Mesalazine renal monitoring — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsMesalazine renal monitoringGPhC CRA

A 29-year-old man prescribed mesalazine MR tablets for ulcerative colitis says he has new severe flank pain and dark urine. He has taken ibuprofen daily for a sports injury and has not had blood tests for 8 months. What monitoring is required?

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Correct answer: A — Renal function assessment and urgent clinical review

Mesalazine can rarely cause renal toxicity, and NSAID use may compound renal risk. Flank pain, dark urine and absent monitoring make urgent assessment appropriate. Renal function should be checked at baseline and periodically during therapy according to local guidance.

Reference: BNF