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Carbimazole agranulocytosis — GPhC CRA MCQ

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HardAdverse Drug Reactions and SafetyCarbimazole agranulocytosisGPhC CRA

A patient prescribed carbimazole 20 mg daily for Graves' disease phones with sore throat, mouth ulcers and fever 38.4°C. She asks whether to buy paracetamol and continue treatment. What monitoring is required?

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Correct answer: D — Urgent full blood count and immediate prescriber contact

Carbimazole can cause agranulocytosis, and sore throat or fever should be treated as a warning symptom. A full blood count is required urgently and the prescriber should be contacted. Paracetamol may mask fever and should not delay assessment.

Reference: BNF