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Amitriptyline adverse effects — GPhC CRA MCQ

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EasyCNS TherapeuticsAmitriptyline adverse effectsGPhC CRA

A 52-year-old man taking amitriptyline 25 mg at night for neuropathic pain asks for advice about dry mouth and constipation. He has no red-flag symptoms and has found the medicine helpful. What would you advise the patient?

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Correct answer: C — Suggest saliva measures, constipation advice and prescriber review if troublesome

Dry mouth and constipation are common anticholinergic effects of amitriptyline. Practical advice includes sugar-free gum or saliva substitutes, hydration, fibre and review of constipation management. Abrupt cessation may worsen symptoms, so persistent or severe adverse effects should be discussed with the prescriber.

Reference: BNF; NICE CKS