skip to main content

Lamotrigine and combined contraception — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardDrug InteractionsLamotrigine and combined contraceptionGPhC CRA

A 19-year-old student taking lamotrigine for epilepsy starts a combined oral contraceptive. She later reports increased seizure frequency during active pills and dizziness during the pill-free interval. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: CRefer for specialist review of lamotrigine and contraception

Oestrogen-containing contraceptives can reduce lamotrigine concentrations, and levels may rise during the hormone-free interval. The pattern of seizures and dizziness fits fluctuating lamotrigine exposure. Specialist review is needed to optimise seizure control and contraception safely.

Reference: BNF; FSRH guidance