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Valproate pregnancy prevention — GPhC CRA MCQ

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HardCNS TherapeuticsValproate pregnancy preventionGPhC CRA

A 31-year-old woman taking sodium valproate for epilepsy asks for an emergency supply while travelling. Her PMR confirms long-term use, but she is sexually active and says she is not using contraception. What is the most appropriate action?

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Correct answer: DSupply if clinically justified and urgently refer for valproate safety review

Abrupt interruption of antiepileptic therapy may cause seizures, so emergency supply may be clinically justified if legal conditions are met. However, valproate has major teratogenic risk and strict pregnancy-prevention requirements, making urgent specialist review essential. The pharmacist should provide safety counselling and document the intervention.

Reference: BNF; MHRA Drug Safety Update