skip to main content

Bisphosphonate in renal impairment — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardRenal and Hepatic ImpairmentBisphosphonate in renal impairmentGPhC CRA

A 64-year-old woman with eGFR 26 mL/min/1.73 m2 is prescribed alendronic acid 70 mg weekly after a fragility fracture. Serum calcium is normal and she has reflux symptoms requiring daily lansoprazole. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Query alendronic acid suitability because renal function is below usual threshold

Oral bisphosphonates have renal function thresholds and are usually avoided in severe renal impairment. This patient also has reflux symptoms that may affect tolerability and administration safety. The prescriber should review osteoporosis treatment choice before supply.

Reference: BNF; NICE CKS