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Methotrexate dispensing error prevention — GPhC CRA MCQ

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HardDispensing and SupplyMethotrexate dispensing error preventionGPhC CRA

A patient prescribed methotrexate 2.5 mg tablets weekly receives a prescription that states 'Take 6 tablets daily as directed' in the directions field, but the clinic letter says 15 mg once weekly. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Do not dispense until the dosing discrepancy is resolved with the prescriber

Methotrexate dosing errors can be fatal, especially when weekly dosing is accidentally written as daily. A discrepancy between prescription directions and the clinic letter must be resolved before supply. The final label should state the weekly dose clearly and specify the day of the week where possible.

Reference: BNF; MEP; NHS England patient safety alerts