skip to main content

Colchicine renal impairment and macrolide — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardRenal and Hepatic ImpairmentColchicine renal impairment and macrolideGPhC CRA

A 69-year-old man with eGFR 18 mL/min/1.73 m2 is prescribed colchicine 500 micrograms twice daily for acute gout. He also takes clarithromycin for chest infection. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Urgently query colchicine because renal impairment and clarithromycin increase toxicity risk

Colchicine has a narrow therapeutic index and toxicity risk increases in renal impairment. Clarithromycin can markedly increase colchicine exposure through CYP3A4 and P-gp inhibition, creating a potentially serious interaction. The prescription should be queried before supply.

Reference: BNF; SPS; NICE CKS