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Gabapentin renal dosing and falls — GPhC CRA MCQ

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HardCNS TherapeuticsGabapentin renal dosing and fallsGPhC CRA

A 70-year-old man with chronic kidney disease and neuropathic pain is prescribed gabapentin 300 mg three times daily. He is unsteady, takes zopiclone at night, and his eGFR is 28 mL/min/1.73 m2. What is the most appropriate action?

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Correct answer: A — Query dose and sedation risk before supply

Gabapentin is renally cleared and dose adjustment is required in renal impairment. Older age, unsteadiness, and concurrent sedatives increase falls and respiratory depression risk. The pharmacist should query dose appropriateness and counsel on sedation and driving risks.

Reference: BNF; NICE CKS