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Analgesia in cirrhosis — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentAnalgesia in cirrhosisGPhC CRA

A 49-year-old man with cirrhosis asks to buy paracetamol and ibuprofen for dental pain. He has ascites, takes spironolactone and furosemide, and drinks no alcohol currently. What is the most appropriate action?

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Correct answer: C — Avoid OTC NSAID use and refer for individual analgesia advice

NSAIDs can worsen renal function, fluid retention, and gastrointestinal bleeding risk in cirrhosis, especially with ascites and diuretics. Paracetamol may be used in liver disease at appropriate reduced dosing in many patients, but this patient needs individual advice given cirrhosis and dental pain. Referral for dental and clinical assessment is appropriate.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-92