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MAOI and pseudoephedrine — GPhC CRA MCQ

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HardDrug InteractionsMAOI and pseudoephedrineGPhC CRA

A patient taking phenelzine for treatment-resistant depression asks to buy pseudoephedrine tablets for nasal congestion. Blood pressure today is 142/88 mmHg. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Pseudoephedrine with an MAOI may precipitate hypertensive crisis

Sympathomimetic decongestants such as pseudoephedrine can interact dangerously with monoamine oxidase inhibitors. The result may be severe hypertension or hypertensive crisis. A non-sympathomimetic option and appropriate medical advice should be considered.

Reference: BNF; MEP