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Bisphosphonate administration labelling — GPhC CRA MCQ

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ModerateDispensing and SupplyBisphosphonate administration labellingGPhC CRA

A patient prescribed alendronic acid 70 mg once weekly asks why the label says to take it with plain water and remain upright. She usually takes medicines with tea in bed. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Take it on waking with plain water and remain upright before food or other medicines

Alendronic acid has poor absorption and can cause oesophageal irritation. It should be taken after getting up with plain water, before food, drinks, and other medicines, and the patient should remain upright for the advised period. Taking it in bed or with tea would increase risk and reduce efficacy.

Reference: BNF; NICE CKS