skip to main content

Digoxin and verapamil — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardDrug InteractionsDigoxin and verapamilGPhC CRA

A 68-year-old woman takes digoxin 125 micrograms daily for atrial fibrillation. A cardiology letter adds verapamil modified-release 240 mg daily for rate control; she has eGFR 45 mL/min/1.73 m2. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Verapamil can increase digoxin concentration and bradycardia risk

Verapamil can increase digoxin levels and has additive effects on atrioventricular nodal conduction. Older age and reduced renal function increase the risk of clinically significant digoxin toxicity or bradycardia. The prescriber should consider dose adjustment and monitoring.

Reference: BNF; SPS