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Methotrexate weekly dosing — GPhC CRA MCQ

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EasyPatient Counselling and Pharmaceutical CareMethotrexate weekly dosingGPhC CRA

A 49-year-old woman starts methotrexate 15 mg once weekly for rheumatoid arthritis. She also receives folic acid 5 mg weekly and asks whether methotrexate is taken every morning like her other tablets. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Take methotrexate once weekly on the agreed day and folic acid on a different day

Low-dose methotrexate for inflammatory disease is taken once weekly, and daily dosing errors can be fatal. Folic acid is used to reduce adverse effects and is usually taken on a different day from methotrexate. The patient should be counselled to report sore throat, mouth ulcers, breathlessness, bruising, or signs of infection.

Reference: BNF; SPS; MEP