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SSRI and tramadol — GPhC CRA MCQ

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ModerateCNS TherapeuticsSSRI and tramadolGPhC CRA

A 44-year-old man taking sertraline 100 mg daily buys tramadol online for dental pain. He asks whether he can take it tonight while waiting for an appointment. What is the most important interaction to flag?

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Correct answer: A — Sertraline with tramadol increases serotonin syndrome and seizure risk

Tramadol has serotonergic activity and can lower seizure threshold. Combined use with an SSRI such as sertraline increases the risk of serotonin syndrome and seizures. The patient should be advised against unsupervised use and directed to urgent dental and analgesic advice.

Reference: BNF; NICE CKS