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Montelukast neuropsychiatric effects — GPhC CRA MCQ

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HardRespiratory TherapeuticsMontelukast neuropsychiatric effectsGPhC CRA

A 15-year-old patient with asthma has been started on montelukast. His parent reports new nightmares, low mood, and agitation within 2 weeks of treatment; asthma symptoms are otherwise stable. What is the most appropriate action?

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Correct answer: BRefer promptly to the prescriber to review montelukast and mental health symptoms

Montelukast has been associated with neuropsychiatric reactions, including sleep disturbance, mood changes, and agitation. New mental health symptoms after initiation warrant prompt clinical review and safety-netting. Stopping inhaled corticosteroid would risk asthma deterioration and does not address the suspected adverse effect.

Reference: BNF; MHRA; NICE CKS