A 31-year-old woman taking lamotrigine for epilepsy presents with a new widespread rash, fever, and mouth soreness after a recent dose increase. She

Question

A 31-year-old woman taking lamotrigine for epilepsy presents with a new widespread rash, fever, and mouth soreness after a recent dose increase. She asks whether to continue until her neurology appointment next month. What is the most appropriate action?

Accepted Answer

Advise urgent medical assessment because severe cutaneous reaction is possible

Answer

Recommend an antihistamine and continue lamotrigine at the same dose

Answer

Apply hydrocortisone cream and avoid sunlight exposure

Answer

Switch to carbamazepine from the next scheduled dose

Answer

Reduce lamotrigine to the previous dose and review in 4 weeks

Lamotrigine rash — GPhC CRA MCQ

A 31-year-old woman taking lamotrigine for epilepsy presents with a new widespread rash, fever, and mouth soreness after a recent dose increase. She asks whether to continue until her neurology appointment next month. What is the most appropriate action?