A patient develops jaundice, dark urine, and severe fatigue 6 weeks after starting flucloxacillin for recurrent cellulitis prophylaxis. The

Question

A patient develops jaundice, dark urine, and severe fatigue 6 weeks after starting flucloxacillin for recurrent cellulitis prophylaxis. The prescriber asks whether this should be reported. What is the most appropriate action?

Accepted Answer

Submit a Yellow Card report and advise urgent clinical review

Answer

Report it if the patient requires liver transplantation

Answer

Advise rechallenge with flucloxacillin to confirm causality

Answer

Switch to co-amoxiclav and wait for symptoms to settle

Answer

Record it locally without reporting because hepatotoxicity is expected

Flucloxacillin hepatotoxicity — GPhC CRA MCQ

A patient develops jaundice, dark urine, and severe fatigue 6 weeks after starting flucloxacillin for recurrent cellulitis prophylaxis. The prescriber asks whether this should be reported. What is the most appropriate action?