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Nitrofurantoin renal function — GPhC CRA MCQ

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HardInfectionsNitrofurantoin renal functionGPhC CRA

A 74-year-old woman is prescribed nitrofurantoin 100 mg modified-release twice daily for lower UTI. Her recent renal function shows eGFR 34 mL/min/1.73 m2, she is afebrile, and she has no flank pain. What is the most appropriate action?

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Correct answer: A — Query suitability and duration before supply because renal function is borderline

Nitrofurantoin efficacy and safety depend on renal function, and use at reduced eGFR needs careful checking against current guidance and indication. In a lower UTI with eGFR around 34 mL/min/1.73 m2, supply may be possible in some circumstances, but the pharmacist should confirm appropriateness and duration. The pharmacist should not independently substitute a different antibiotic.

Reference: BNF; NICE CKS