A 70-year-old man with non-valvular AF collects edoxaban 30mg once daily. His record shows body weight 54kg, creatinine clearance 46mL/min and

Question

A 70-year-old man with non-valvular AF collects edoxaban 30mg once daily. His record shows body weight 54kg, creatinine clearance 46mL/min and concomitant verapamil. He asks why his neighbour takes a higher dose. What would you advise the patient?

Accepted Answer

The lower edoxaban dose is appropriate because his clinical factors increase exposure.

Answer

The dose should be increased because verapamil reduces edoxaban concentration.

Answer

The lower dose is used because AF is less serious than venous thromboembolism.

Answer

The dose should be taken twice daily when body weight is below 60kg.

Answer

The dose should be replaced by aspirin when creatinine clearance is below 50mL/min.

Edoxaban dose reduction — GPhC CRA MCQ

A 70-year-old man with non-valvular AF collects edoxaban 30mg once daily. His record shows body weight 54kg, creatinine clearance 46mL/min and concomitant verapamil. He asks why his neighbour takes a higher dose. What would you advise the patient?