skip to main content

Amitriptyline anticholinergic burden — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardCNS TherapeuticsAmitriptyline anticholinergic burdenGPhC CRA

A 70-year-old man takes amitriptyline 25mg at night for neuropathic pain. He has glaucoma, urinary hesitancy and recent falls. His daughter asks whether to request a dose increase because pain persists. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Ask the prescriber to review treatment because anticholinergic burden and falls risk are significant.

Amitriptyline has anticholinergic effects and can worsen urinary retention, glaucoma and falls risk in older people. Persistent pain should prompt a treatment review rather than automatic dose escalation. Adding further anticholinergic medicines would increase risk.

Reference: BNF; NICE CKS