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Amlodipine ankle oedema — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsAmlodipine ankle oedemaGPhC CRA

A 63-year-old woman started amlodipine 10mg daily six weeks ago. She now has bilateral ankle swelling but no breathlessness, chest pain or calf tenderness. Her BP is controlled and renal function is stable. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Discuss reducing or switching amlodipine after prescriber review.

Peripheral oedema is a common dose-related adverse effect of dihydropyridine calcium-channel blockers and is not usually caused by sodium and water retention. Diuretics are often ineffective for this mechanism. If BP is controlled but oedema is troublesome, dose reduction or switching should be discussed with the prescriber.

Reference: BNF; NICE CKS