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Long-term PPI review — GPhC CRA MCQ

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ModerateGI TherapeuticsLong-term PPI reviewGPhC CRA

A 66-year-old woman has taken omeprazole 20mg daily for dyspepsia for eight months. Endoscopy was normal, she has no weight loss, dysphagia or GI bleeding, and symptoms have settled. What is the most appropriate alternative?

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Correct answer: C — Discuss step-down or review of ongoing PPI need with the prescriber.

Long-term PPI use should be reviewed, particularly when symptoms have settled and alarm features are absent. Step-down to the lowest effective dose, intermittent use or stopping may be appropriate. Increasing the dose indefinitely would increase exposure without clear indication.

Reference: NICE CKS; BNF