Rifampicin and combined oral contraception — GPhC CRA MCQ
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Correct answer: E — Rifampicin can reduce contraceptive efficacy through enzyme induction.
Rifampicin is a potent enzyme inducer and can reduce exposure to hormonal contraceptives, risking contraceptive failure. The patient needs advice about reliable non-hormonal or specialist-recommended contraception during and after rifampicin therapy. This interaction is clinically important even with good pill adherence.
Reference: BNF; Faculty of Sexual and Reproductive Healthcare guidance